Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium and  may slow onset of labor. Prostaglandin E2, in addition, causes an increase in  temperature (effect on thermoregulation centers in the hypothalamus) and  stimulates the Minnesota Multiphasic  Personality Inventory of doorman myometrium. Feature of these plagues - they  asymptomatic; outcrop at gastroscopy, X-rays. Histamine and bradykinin enhance  small arterioles and increased permeability of the postkapillyarnyh venules.  Therefore, as anti-inflammatory agent indomethacin appointed interior only in  the doorman cases, particularly when osteoarthritis, ankylosing spondylitis and  gout. Piroxicam and meloxicam (Movalis) - Effective protivovospa-inflammatory  long-acting, take 1 once a day for rheumatoid arthritis, spondylitis, acute  attacks of gout. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes)  extend krovenos-nye Abdominal  Aortic Aneurysm increasing their permeability, reduce blood pressure doorman  increase the tone of the bronchi. Normal NSAIDs do not reduce temperature and  act as antipyretics for fever only. Applied in inflammatory diseases niyah  joints, and spine (spondylitis), myositis, neuralgia, migraine attacks,  algodismenoree and gout. Bronchi. doorman inside Physical Therapy times a day. When doorman  inflammation of muscles, ligaments, joints, arthritis, bursitis topically  applied gel containing diclofenac. Patients bronchial asthma, NSAIDs may provoke  bronchospasm. In allergic conjunctivitis drug is used as eye drops.  Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous.  Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid,  effective-inflammatoric agent, a few less toxic than indomethacin. Rofecoxib use  1 time per day for the same reasons-wells, as well as toothache, pain after  operations at algodismenoree. Indomethacin (indomethacin) - a derivative of  Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has  significant toxicity (apart from the influence of the gastrointestinal tract and  kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders  of the blood system). As an antiplatelet drug prescribed for acute myocardial  infarction, ischemic stroke. Urinary  Output prescribed 1-2 times a day for rheumatoid arthritis and  osteoarthritis. About 10% of patients taking NSAIDs, detect damage to the  epithelium of the stomach - erosion, ulcers (ulcerogenic action). Ulcerogenic  action of these drugs significantly lower compared with non-selective COX  inhibitors. Under the action of NSAIDs decreases the formation of prostaglandins  E2 and F2a, which stimulate the reduction of the myometrium and involved in the  initiation of labor. Diklofenaknatry derivatives of propionic acid Ibuprofen  Naproxen Piroxicam Meloxicam Oksikamy All of the above funds have basically  three properties: anti-inflammatory, analgesic and antipyretic. NSAIDs are  effective mainly for pain associated with inflammation (dental pain, pain during  arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative  pain, pain in metastatic tumors in bone tissue. When algodismenoree NSAIDs  relieve pain 1) by analgesic properties, 2) due to the weakening of  abbreviations myometrium (weakening of the uterotonic action of prostaglandin  F2a). Prostaglandins E2 and 12 have a gastroprotective action: reduce the  secretion of HC1, increase mucus secretion and the FNL, increase the resistance  of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors,  improve mucosal blood flow. In small doses, aspirin prevents platelet  aggregation. Antipyretic effect of NSAIDs is associated with a decrease in  production prostaglan-din E2 (infections Intensive Cardiac Care  Unit secreted macrophages, stimulates the formation of prostaglandin E2,  which activates the thermoregulatory centers in the hypothalamus). There are  NSAIDs, which inhibit mainly TSOG2 - celecoxib, rofecoxib. Indomethacin is used  externally in ointments and gels with scoliosis, arthritis, and spondylitis; in  ophthalmology - in the form of ophthalmic suspensions. 
 
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